EIF4A1

Across TCGA pan-cancer cohorts, EIF4A1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EIF4A1 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EIF4A1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF4A1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

KIRC, ACC, and UVM are the cancer types where EIF4A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.534	0.708	<.001	96	view →
ACC	DFS	Median	All	0.380	0.772	<.001	92	view →
UVM	DFS	Quartile	II,III,IV	0.290	0.816	<.001	91	view →
BRCA	OS	Median	III,IV	0.946	0.857	.010	28	view →
SARC	OS	Quartile	All	0.356	0.648	<.001	27	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
BLCA	DFS	Median	II,III,IV	0.408	0.283	.016	20	view →
PRAD	DFS	Median	All	0.699	0.840	<.001	18	view →
LGG	DFS	Quartile	All	0.757	0.894	<.001	16	view →
HNSC	OS	Tertile	II,III,IV	0.692	0.564	.006	16	view →
COAD	DFS	Median	II,III,IV	0.345	0.647	.004	15	view →
THCA	OS	Quartile	II,III,IV	0.887	0.990	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EIF4A1–KIRC (DFS)

Open the KIRC breakdown →