EIF4A1

Across TCGA cell cohorts, EIF4A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,768 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible EIF4A1-associated GO terms across cancer lineages are Telomere assembly, 'de novo' IMP biosynthetic process, and Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with EIF4A1 in more than 18 cancer types. Because this analysis shows association rather than direction, both EIF4A1-to-partner and partner-to-EIF4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere assembly grouped by EIF4A1-low versus EIF4A1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF4A1→partner) and Y-score (partner→EIF4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Telomere assembly →	+0.178	+0.766	.001	.004	2	19
BREAST	'de novo' IMP biosynthetic process →	+0.142	+0.979	<.001	<.001	3	17
OVARY	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.118	+0.930	<.001	<.001	3	17
OVARY	DNA replication initiation →	+0.139	+0.975	<.001	<.001	3	16
OVARY	rRNA processing →	+0.119	+1.120	<.001	<.001	3	16
KIDNEY	'de novo' AMP biosynthetic process →	+0.175	+0.664	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,768 associations by consensus.

Telomere assembly by EIF4A1 expression — OESOPHAGUS

Explore this box plot interactively →