EIF3J

Across TCGA patient cohorts, EIF3J mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3J-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and A-Raf_pS299. Each is linked with EIF3J in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3J-to-partner and partner-to-EIF3J results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by EIF3J-low versus EIF3J-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3J→partner) and Y-score (partner→EIF3J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.264	+2.459	.008	.018	3	2
UCEC	EGFR_pY1068 →	-0.275	-2.736	.002	<.001	3	1
UCEC	A-Raf_pS299 →	-0.146	-4.000	<.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.094	-1.502	.040	.030	3	1
UCEC	GSK-3_pS9 →	-0.359	-1.807	.015	.024	3	1
UCEC	MAPK_pT202_Y204 →	-0.472	-2.571	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

4E-BP1 by EIF3J expression — UCEC

Explore this box plot interactively →