EIF3J

Across TCGA pan-cancer cohorts, EIF3J RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EIF3J data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF3J RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EIF3J expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

HNSC, ACC, and BLCA are the cancer types where EIF3J RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.693	0.811	<.001	127	view →
ACC	DFS	Median	All	0.277	0.632	<.001	88	view →
BLCA	OS	Tertile	All	0.502	0.677	<.001	79	view →
UVM	DFS	Quartile	III,IV	0.195	0.922	<.001	56	view →
KIRP	DFS	Tertile	All	0.878	0.981	.003	47	view →
LUAD	OS	Tertile	All	0.739	0.847	.005	36	view →
KICH	DFS	Median	III,IV	0.289	0.901	.002	32	view →
LIHC	DFS	Tertile	All	0.434	0.638	.001	29	view →
PAAD	OS	Quartile	All	0.196	0.625	<.001	26	view →
KIRC	DFS	Quartile	All	0.839	0.671	.015	24	view →
MESO	OS	Median	All	0.426	0.671	.002	22	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EIF3J–HNSC (OS)

Open the HNSC breakdown →