EIF3I

Across TCGA patient cohorts, EIF3I mutation is significantly associated with the RNA expression of many other genes, with 1,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3I-associated genes across cancer lineages are MRPS18C, OXSM, and IGHD4-17. Each is linked with EIF3I in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF3I-to-partner and partner-to-EIF3I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS18C grouped by EIF3I-low versus EIF3I-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3I→partner) and Y-score (partner→EIF3I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS18C →	+0.352	+2.767	<.001	.002	3	3
UCEC	OXSM →	+0.407	+2.642	<.001	.005	3	3
UCEC	IGHD4-17 →	+0.656	+2.492	<.001	.008	3	3
SKCM	SRP72P1 →	+0.067	+2.050	<.001	.004	3	2
CESC	LINC02293 →	+0.118	+4.786	<.001	.001	3	2
CESC	BNIP3P38 →	+0.098	+4.060	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,284 associations by consensus.

MRPS18C by EIF3I expression — SKCM

Explore this box plot interactively →