EIF3I

Across TCGA pan-cancer cohorts, EIF3I RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of EIF3I’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EIF3I RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF3I is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where EIF3I tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF3I RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.522	<.001	12	view →
COAD	Female	II,III,IV	+0.960	<.001	11	view →
HNSC	Male	All	+0.502	<.001	11	view →
LUAD	Female	II,III,IV	+0.666	<.001	9	view →
LIHC	Female	II,III,IV	+0.821	<.001	8	view →
STAD	Male	II,III,IV	+0.801	<.001	8	view →
LUSC	Female	All	+0.744	<.001	8	view →
BLCA	All	All	+0.557	<.001	8	view →
THCA	All	II,III,IV	+0.287	<.001	8	view →
KICH	Female	II,III,IV	−1.495	<.001	7	view →
UCEC	All	All	+0.390	.001	6	view →
CHOL	Male	All	+1.501	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

EIF3I–KIRC

Open the KIRC breakdown →