EIF3I

Across TCGA cell cohorts, EIF3I RNA expression is significantly associated with the go_rna of many other GO terms, with 3,646 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible EIF3I-associated GO terms across cancer lineages are DNA replication initiation, mRNA splicing, via endonucleolytic cleavage and ligation, and Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with EIF3I in more than 12 cancer types. Because this analysis shows association rather than direction, both EIF3I-to-partner and partner-to-EIF3I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by EIF3I-low versus EIF3I-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3I→partner) and Y-score (partner→EIF3I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNA replication initiation →	+0.119	+0.552	<.001	<.001	3	13
KIDNEY	mRNA splicing, via endonucleolytic cleavage and ligation →	+0.132	+0.734	.003	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.131	+0.843	<.001	<.001	3	11
BREAST	7-methylguanosine cap hypermethylation →	+0.092	+0.730	.001	<.001	3	11
URINARY_TRACT	Maturation of SSU-rRNA →	+0.106	+0.692	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Protein import into mitochondrial intermembrane space →	+0.145	+0.870	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,646 associations by consensus.

DNA replication initiation by EIF3I expression — SKIN

Explore this box plot interactively →