EIF3H

Across TCGA patient cohorts, EIF3H mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3H-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and JNK2. Each is linked with EIF3H in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3H-to-partner and partner-to-EIF3H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EIF3H-low versus EIF3H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3H→partner) and Y-score (partner→EIF3H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.308	-2.459	.011	.020	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.694	+3.584	.004	.002	3	1
UCEC	JNK2 →	+0.393	+3.179	<.001	.010	3	1
UCEC	MEK1 →	+0.459	+3.321	.009	.010	3	1
UCEC	Tuberin →	+0.430	+2.459	<.001	.020	3	1
UCEC	VHL →	-1.159	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by EIF3H expression — UCEC

Explore this box plot interactively →