EIF3H

Across TCGA pan-cancer cohorts, EIF3H RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EIF3H’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EIF3H RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF3H is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where EIF3H tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF3H RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.453	<.001	12	view →
HNSC	All	IV	+0.516	<.001	11	view →
COAD	Male	IV	+1.154	<.001	10	view →
LIHC	Male	II,III,IV	+1.616	<.001	9	view →
BRCA	All	III,IV	+0.682	<.001	6	view →
LUAD	All	All	+0.402	<.001	6	view →
CHOL	Male	All	+2.260	<.001	5	view →
READ	All	All	+0.759	<.001	5	view →
LUSC	Male	All	+0.444	<.001	5	view →
STAD	Male	II,III,IV	+0.649	<.001	4	view →
KIRP	All	II,III,IV	+0.416	.003	4	view →
KICH	Female	All	−0.894	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EIF3H–KIRC

Open the KIRC breakdown →