EIF3D

Across TCGA patient cohorts, EIF3D mutation is significantly associated with the RNA expression of many other genes, with 304 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF3D-associated genes across cancer lineages are MIR4510, ATXN3L, and OR6K2. Each is linked with EIF3D in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3D-to-partner and partner-to-EIF3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by EIF3D-low versus EIF3D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3D→partner) and Y-score (partner→EIF3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4510 →	+0.200	+5.163	<.001	.002	3	2
CESC	ATXN3L →	+0.021	+4.837	<.001	.003	3	2
CESC	OR6K2 →	+0.020	+4.837	<.001	.003	3	2
CESC	RNU6-1188P →	+0.222	+3.411	.001	.009	3	2
UCEC	RNU4-58P →	+0.255	+2.963	<.001	.003	3	2
UCEC	RNA5SP149 →	+1.344	+3.832	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 304 associations by consensus.

MIR4510 by EIF3D expression — SKCM

Explore this box plot interactively →