EIF3A

Across TCGA cell cohorts, EIF3A mutation is significantly associated with the RNA expression of many other genes, with 596 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF3A-associated genes across cancer lineages are ZIC5, TUBAL3, and SOX8. Each is linked with EIF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF3A-to-partner and partner-to-EIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by EIF3A-low versus EIF3A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF3A→partner) and Y-score (partner→EIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZIC5 →	+0.794	+3.426	<.001	.007	3	2
BLOOD_Leukemia	TUBAL3 →	+1.233	+3.257	.003	.009	3	2
BLOOD_Leukemia	SOX8 →	+0.524	+3.318	.008	.007	3	2
BLOOD_Leukemia	WSCD2 →	+0.707	+2.918	.001	.005	3	2
LARGE_INTESTINE	ATP5F1B →	+0.607	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	PPIL4 →	+0.521	+2.628	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 596 associations by consensus.

ZIC5 by EIF3A expression — BLOOD_Leukemia

Explore this box plot interactively →