EIF2S2P3

Across TCGA pan-cancer cohorts, EIF2S2P3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of EIF2S2P3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EIF2S2P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF2S2P3 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where EIF2S2P3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF2S2P3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.307	<.001	12	view →
LIHC	All	II,III,IV	+0.259	<.001	8	view →
HNSC	All	II,III,IV	+0.153	.005	7	view →
READ	All	II,III,IV	+0.272	.003	6	view →
STAD	All	IV	+0.526	.006	5	view →
BLCA	All	III,IV	−0.207	.020	5	view →
THCA	Male	All	−0.501	<.001	4	view →
CHOL	All	All	+0.667	.002	3	view →
LUSC	Female	All	−0.246	.024	2	view →
KIRC	All	All	+0.052	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

EIF2S2P3–COAD

Open the COAD breakdown →