EIF2D

Across TCGA pan-cancer cohorts, EIF2D mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated EIF2D data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF2D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF2D expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where EIF2D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.328	0.889	.014	21	view →
UCEC	OS	Tertile	II,III,IV	0.344	1.000	.009	20	view →
PDAC	DFS	Median	All	0.855	0.735	.009	16	view →
COAD	DFS	Median	III,IV	1.000	0.889	.027	12	view →
GBM	DFS	Tertile	All	0.699	0.896	.007	11	view →
CCRCC	OS	Median	III,IV	0.946	0.657	.025	2	view →
LUAD	OS	Median	All	0.916	0.777	.027	2	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

EIF2D–HNSC (DFS)

Open the HNSC breakdown →