EIF2AK4

Across TCGA patient cohorts, EIF2AK4 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2AK4-associated genes across cancer lineages are FoxM1, TIGAR, and ASNS. Each is linked with EIF2AK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both EIF2AK4-to-partner and partner-to-EIF2AK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by EIF2AK4-low versus EIF2AK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK4→partner) and Y-score (partner→EIF2AK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.185	+1.637	.015	.001	3	5
UCEC	TIGAR →	+0.110	+1.514	.014	.014	3	3
UCEC	ASNS →	+0.263	+1.152	.013	.048	3	3
COAD	GAPDH →	+0.578	+2.178	.015	.035	3	3
UCEC	eIF4E →	+0.183	+1.857	.003	<.001	3	2
UCEC	Ku80 →	+0.212	+1.254	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FoxM1 by EIF2AK4 expression — UCEC

Explore this box plot interactively →