EIF2AK4

Across TCGA pan-cancer cohorts, EIF2AK4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of EIF2AK4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EIF2AK4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF2AK4 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

HNSC, THCA, and STAD are the cancer types where EIF2AK4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF2AK4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.303	<.001	12	view →
THCA	All	All	−0.340	<.001	8	view →
STAD	Male	II,III,IV	+0.814	.001	6	view →
BLCA	All	All	+0.459	.002	6	view →
COAD	All	All	+0.374	<.001	6	view →
ESCA	All	All	+0.589	<.001	4	view →
LUSC	All	All	+0.325	.001	4	view →
CHOL	Male	All	+1.076	.001	2	view →
PRAD	All	All	+0.488	<.001	2	view →
LUAD	Male	II,III,IV	+0.402	.021	2	view →
KIRC	All	All	+0.257	.001	2	view →
LIHC	Female	All	+0.345	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

EIF2AK4–HNSC

Open the HNSC breakdown →