EIF2AK4

Across TCGA cell cohorts, EIF2AK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,911 significant associations in total. CNS shows the largest number of these associations.

The most reproducible EIF2AK4-associated GO terms across cancer lineages are Negative regulation of translational initiation in response to stress, GCN2-mediated signaling, and Positive regulation of translational initiation. Each is linked with EIF2AK4 in more than 14 cancer types. Because this analysis shows association rather than direction, both EIF2AK4-to-partner and partner-to-EIF2AK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translational initiation in response to stress grouped by EIF2AK4-low versus EIF2AK4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK4→partner) and Y-score (partner→EIF2AK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of translational initiation in response to stress →	+0.143	+1.235	<.001	<.001	3	15
BLOOD_Myeloma	GCN2-mediated signaling →	+0.198	+1.189	.002	<.001	3	13
STOMACH	Positive regulation of translational initiation →	+0.129	+1.082	<.001	.003	3	11
STOMACH	Positive regulation of translational initiation in response to stress →	+0.148	+0.971	.002	.002	3	10
BLOOD_Myeloma	Positive regulation of translation in response to stress →	+0.177	+1.242	.003	.001	3	9
LUNG_NSCLC_LUSC	Viral translation →	+0.111	+1.177	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,911 associations by consensus.

Negative regulation of translational initiation in response to stress by EIF2AK4 expression — BLOOD_Myeloma

Explore this box plot interactively →