EIF2AK4

Across TCGA cell cohorts, EIF2AK4 mutation is significantly associated with the RNA expression of many other genes, with 1,940 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EIF2AK4-associated genes across cancer lineages are CCDC134, POLDIP3, and TNRC6B. Each is linked with EIF2AK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2AK4-to-partner and partner-to-EIF2AK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC134 grouped by EIF2AK4-low versus EIF2AK4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK4→partner) and Y-score (partner→EIF2AK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC134 →	+0.893	+3.453	<.001	.001	3	2
LARGE_INTESTINE	POLDIP3 →	+0.522	+3.192	.004	.007	3	2
LARGE_INTESTINE	TNRC6B →	+0.948	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ST13 →	+0.534	+3.169	.001	.009	3	2
BLOOD_Leukemia	ZBED4 →	+0.528	+3.321	.008	.005	3	2
LARGE_INTESTINE	METTL4 →	+0.584	+2.628	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,940 associations by consensus.

CCDC134 by EIF2AK4 expression — LARGE_INTESTINE

Explore this box plot interactively →