EIF2AK3

Across TCGA patient cohorts, EIF2AK3 mutation is significantly associated with the RNA expression of many other genes, with 4,937 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2AK3-associated genes across cancer lineages are H3Y1, BRAT1, and BAP1. Each is linked with EIF2AK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EIF2AK3-to-partner and partner-to-EIF2AK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3Y1 grouped by EIF2AK3-low versus EIF2AK3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK3→partner) and Y-score (partner→EIF2AK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	H3Y1 →	+0.937	+2.533	<.001	.002	3	3
UCEC	BRAT1 →	+0.280	+1.549	.006	.002	3	3
UCEC	BAP1 →	+0.262	+1.688	.003	.001	3	3
UCEC	TMUB1 →	+0.272	+2.016	.009	.001	3	3
UCEC	FAXDC2 →	-0.583	-3.237	<.001	<.001	3	3
UCEC	TRABD →	+0.380	+1.720	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,937 associations by consensus.

H3Y1 by EIF2AK3 expression — LUSC

Explore this box plot interactively →