EIF2AK3

Across TCGA pan-cancer cohorts, EIF2AK3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated EIF2AK3 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher EIF2AK3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated EIF2AK3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRP, and KIRC are the cancer types where EIF2AK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Quartile	III,IV	0.496	0.260	<.001	78	view →
KIRP	DFS	Tertile	III,IV	0.498	0.848	.002	62	view →
KIRC	DFS	Tertile	All	0.881	0.703	.003	37	view →
LGG	OS	Median	All	0.747	0.876	<.001	34	view →
LUAD	OS	Quartile	III,IV	0.738	0.314	.001	34	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	30	view →
ACC	DFS	Tertile	All	0.476	0.807	.001	29	view →
HNSC	DFS	Quartile	All	0.833	0.636	<.001	29	view →
UCS	DFS	Tertile	IV	0.832	0.239	.024	24	view →
THYM	DFS	Median	II,III,IV	0.883	0.564	.002	14	view →
GBM	OS	Tertile	All	0.487	0.325	.016	10	view →
COAD	OS	Tertile	All	0.933	0.782	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

EIF2AK3–SKCM (OS)

Open the SKCM breakdown →