EIF2AK3

Across TCGA patient cohorts, EIF2AK3 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2AK3-associated genes across cancer lineages are C-Raf_pS338, ERK2, and FoxM1. Each is linked with EIF2AK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2AK3-to-partner and partner-to-EIF2AK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf_pS338 grouped by EIF2AK3-low versus EIF2AK3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK3→partner) and Y-score (partner→EIF2AK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C-Raf_pS338 →	-0.139	-2.999	.038	.035	3	2
UCEC	ERK2 →	+0.123	+1.137	.043	.041	3	2
UCEC	FoxM1 →	+0.182	+2.807	.025	<.001	3	2
SKCM	p62 Lck ligand →	+0.524	+3.321	.008	.010	3	2
UCEC	PCNA →	+0.212	+1.836	.001	.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.274	-1.794	.020	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

C-Raf_pS338 by EIF2AK3 expression — BLCA

Explore this box plot interactively →