EIF2AK3

Across TCGA cell cohorts, EIF2AK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,433 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EIF2AK3-associated GO terms across cancer lineages are Regulation of translation initiation in response to endoplasmic reticulum stress, Endoplasmic reticulum to cytosol transport, and Retrograde protein transport, ER to cytosol. Each is linked with EIF2AK3 in more than 18 cancer types. Because this analysis shows association rather than direction, both EIF2AK3-to-partner and partner-to-EIF2AK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation initiation in response to endoplasmic reticulum stress grouped by EIF2AK3-low versus EIF2AK3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK3→partner) and Y-score (partner→EIF2AK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.172	+1.120	<.001	<.001	3	19
OESOPHAGUS	Endoplasmic reticulum to cytosol transport →	+0.197	+1.287	<.001	.001	3	17
OESOPHAGUS	Retrograde protein transport, ER to cytosol →	+0.197	+1.287	<.001	.001	3	17
PANCREAS	Negative regulation of myelination →	+0.223	+0.916	<.001	.003	3	17
OESOPHAGUS	Protein exit from endoplasmic reticulum →	+0.179	+1.256	<.001	.001	3	17
BLOOD_Myeloma	Regulation of translation in response to endoplasmic reticulum stress →	+0.194	+2.018	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,433 associations by consensus.

Regulation of translation initiation in response to endoplasmic reticulum stress by EIF2AK3 expression — OESOPHAGUS

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