EIF2AK3

Across TCGA cell cohorts, EIF2AK3 mutation is significantly associated with the RNA expression of many other genes, with 304 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF2AK3-associated genes across cancer lineages are KRTAP4-12, CARTPT, and GOLGA8G. Each is linked with EIF2AK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2AK3-to-partner and partner-to-EIF2AK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-12 grouped by EIF2AK3-low versus EIF2AK3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK3→partner) and Y-score (partner→EIF2AK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP4-12 →	+0.037	+3.169	.003	.008	3	1
SKIN	CARTPT →	+0.022	+3.688	.008	.002	3	1
SKIN	GOLGA8G →	+0.012	+3.196	<.001	.007	3	1
BREAST	ANKRD30BL →	+0.029	+4.672	<.001	.002	3	1
BLOOD_Leukemia	GOT1L1 →	+0.060	+5.569	<.001	.001	3	1
LARGE_INTESTINE	CA2 →	+1.948	+3.257	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 304 associations by consensus.

KRTAP4-12 by EIF2AK3 expression — BLOOD_Lymphoma

Explore this box plot interactively →