EIF2AK3-DT

Across TCGA pan-cancer cohorts, EIF2AK3-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EIF2AK3-DT data layer.

The strongest signal is observed in mesothelioma (MESO), where higher EIF2AK3-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated EIF2AK3-DT expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

MESO, UCS, and SKCM are the cancer types where EIF2AK3-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.473	0.232	.001	60	view →
UCS	DFS	Quartile	II,III,IV	0.645	0.125	.002	54	view →
SKCM	OS	Median	All	0.418	0.259	<.001	49	view →
ACC	DFS	Quartile	II,III,IV	0.159	0.726	.003	36	view →
STAD	OS	Median	IV	0.275	0.753	.003	30	view →
COAD	DFS	Tertile	All	0.598	0.807	.002	26	view →
OV	OS	Quartile	IV	0.544	0.281	.035	16	view →
THCA	OS	Quartile	All	0.940	0.990	.010	13	view →
LIHC	DFS	Median	All	0.491	0.605	.014	13	view →
TGCT	DFS	Quartile	All	0.925	0.665	.005	12	view →
READ	DFS	Median	IV	0.410	0.788	.010	12	view →
BLCA	OS	Quartile	IV	0.232	0.723	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EIF2AK3-DT–MESO (OS)

Open the MESO breakdown →