EIF2AK3-DT

Across TCGA pan-cancer cohorts, EIF2AK3-DT RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EIF2AK3-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where EIF2AK3-DT RNA is repressed in tumor relative to normal tissue. In most cancer types EIF2AK3-DT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where EIF2AK3-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF2AK3-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.818	<.001	11	view →
HNSC	All	All	+0.316	<.001	11	view →
LIHC	Male	All	+0.463	<.001	8	view →
KICH	Male	All	−1.220	<.001	7	view →
UCEC	All	All	−0.516	<.001	6	view →
KIRC	Male	II,III,IV	−0.479	.001	6	view →
BLCA	Female	All	+0.727	.019	5	view →
LUSC	All	All	+0.562	<.001	5	view →
CHOL	All	All	+0.861	<.001	4	view →
COAD	Male	All	+0.213	.026	3	view →
STAD	All	All	+0.201	.015	3	view →
READ	Female	All	+0.581	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EIF2AK3-DT–THCA

Open the THCA breakdown →