EIF2A

Across TCGA patient cohorts, EIF2A protein abundance is significantly associated with the RNA expression of many other genes, with 14,338 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EIF2A-associated genes across cancer lineages are MRPL3, CCDC58, and TOPBP1. Each is linked with EIF2A in more than 7 cancer types. Because this analysis shows association rather than direction, both EIF2A-to-partner and partner-to-EIF2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EIF2A versus MRPL3 in LUAD, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2A→partner) and Y-score (partner→EIF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MRPL3 →	+0.484	+0.279	<.001	<.001	3	8
LSCC	CCDC58 →	+0.624	+0.296	<.001	<.001	3	6
LSCC	TOPBP1 →	+0.693	+0.264	<.001	<.001	3	6
LSCC	MRPS22 →	+0.554	+0.308	<.001	<.001	3	6
LUAD	TRIP13 →	+1.259	+0.303	<.001	<.001	3	6
LSCC	CDKN3 →	+0.888	+0.280	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,338 associations by consensus.

EIF2A vs MRPL3 — LUAD

Explore this scatter interactively →