EIF1AX

Across TCGA patient cohorts, EIF1AX mutation is significantly associated with the RNA expression of many other genes, with 1,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF1AX-associated genes across cancer lineages are POM121L6P, FBXO3-DT, and OR6R2P. Each is linked with EIF1AX in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF1AX-to-partner and partner-to-EIF1AX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POM121L6P grouped by EIF1AX-low versus EIF1AX-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF1AX→partner) and Y-score (partner→EIF1AX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	POM121L6P →	+0.088	+3.834	<.001	.005	3	2
THCA	FBXO3-DT →	+0.194	+3.332	<.001	.008	3	2
THCA	OR6R2P →	+0.245	+4.307	.003	.001	3	2
UCEC	DTWD1 →	+0.282	+2.365	.006	.002	3	2
UCEC	NFKBIB →	+0.304	+2.069	.005	<.001	3	2
UCEC	SLC16A6 →	-0.394	-1.523	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,250 associations by consensus.

POM121L6P by EIF1AX expression — THCA

Explore this box plot interactively →