EGR3

Across TCGA cell cohorts, EGR3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGR3-associated genes across cancer lineages are FAM47B, RND2, and TCF15. Each is linked with EGR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGR3-to-partner and partner-to-EGR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47B grouped by EGR3-low versus EGR3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR3→partner) and Y-score (partner→EGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM47B →	+0.016	+5.029	<.001	.006	3	1
LARGE_INTESTINE	RND2 →	+0.533	+3.302	.006	.008	3	1
LARGE_INTESTINE	TCF15 →	+0.370	+2.556	.001	.006	3	1
LARGE_INTESTINE	AHSP →	+0.034	+2.560	.004	.008	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	LRRC3B →	+0.015	+3.023	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

FAM47B by EGR3 expression — LUNG_SCLC

Explore this box plot interactively →