EGLN1

Across TCGA patient cohorts, EGLN1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGLN1-associated genes across cancer lineages are Tuberin, Caspase-7-cleavedD198, and STAT5a. Each is linked with EGLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGLN1-to-partner and partner-to-EGLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by EGLN1-low versus EGLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGLN1→partner) and Y-score (partner→EGLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.376	+2.817	.007	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.796	+3.019	.010	.019	3	1
UCEC	STAT5a →	+0.619	+3.321	.003	.010	2	1
UCEC	BRCA2 →	-0.148	-2.989	.034	.035	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Tuberin by EGLN1 expression — UCEC

Explore this box plot interactively →