EGFR

Across TCGA cell cohorts, EGFR mutation is significantly associated with the RNA expression of many other genes, with 1,327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGFR-associated genes across cancer lineages are ANKFY1, SHROOM3, and ZNF837. Each is linked with EGFR in more than 3 cancer types. Because this analysis shows association rather than direction, both EGFR-to-partner and partner-to-EGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKFY1 grouped by EGFR-low versus EGFR-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFR→partner) and Y-score (partner→EGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANKFY1 →	+0.519	+3.516	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SHROOM3 →	+1.036	+2.152	.006	.005	3	3
BLOOD_Leukemia	ZNF837 →	+0.660	+3.351	<.001	.003	3	3
BLOOD_Leukemia	RTL6 →	+1.465	+3.351	.003	.003	3	3
BLOOD_Leukemia	CCN5 →	+0.154	+3.351	<.001	.003	3	3
LARGE_INTESTINE	CLEC18B →	+0.626	+3.125	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,327 associations by consensus.

ANKFY1 by EGFR expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →