EGFLAM

Across TCGA patient cohorts, EGFLAM mutation is significantly associated with the RNA expression of many other genes, with 4,162 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGFLAM-associated genes across cancer lineages are PIMREG, CCNB2, and EXO1. Each is linked with EGFLAM in more than 5 cancer types. Because this analysis shows association rather than direction, both EGFLAM-to-partner and partner-to-EGFLAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIMREG grouped by EGFLAM-low versus EGFLAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFLAM→partner) and Y-score (partner→EGFLAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIMREG →	+0.546	+1.523	.001	<.001	3	6
UCEC	CCNB2 →	+0.553	+1.847	<.001	<.001	3	5
UCEC	EXO1 →	+0.432	+1.785	.006	.001	3	5
UCEC	ANP32B →	+0.293	+2.016	.007	<.001	3	5
LUSC	TUBB2A →	+0.681	+3.494	.001	.002	3	5
LUSC	TUBB4B →	+0.477	+1.954	.003	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,162 associations by consensus.

PIMREG by EGFLAM expression — UCEC

Explore this box plot interactively →