EGFLAM

Across TCGA patient cohorts, EGFLAM mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGFLAM-associated genes across cancer lineages are Shc_pY317, Caspase-8, and Cyclin-B1. Each is linked with EGFLAM in more than 2 cancer types. Because this analysis shows association rather than direction, both EGFLAM-to-partner and partner-to-EGFLAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by EGFLAM-low versus EGFLAM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFLAM→partner) and Y-score (partner→EGFLAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Shc_pY317 →	-0.188	-2.106	.004	.018	3	3
UCEC	Caspase-8 →	-0.169	-1.710	.022	.005	3	3
UCEC	Cyclin-B1 →	+0.576	+2.502	<.001	.001	3	3
UCEC	FoxM1 →	+0.166	+1.241	.030	.015	3	3
LUAD	Chk1_pS345 →	+0.105	+2.584	.006	.011	3	2
LUSC	Bim →	-0.246	-2.450	.045	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Shc_pY317 by EGFLAM expression — COAD

Explore this box plot interactively →