EGFLAM

Across TCGA cell cohorts, EGFLAM mutation is significantly associated with the RNA expression of many other genes, with 300 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGFLAM-associated genes across cancer lineages are EEF2, OR10D3, and H4C7. Each is linked with EGFLAM in more than 1 cancer types. Because this analysis shows association rather than direction, both EGFLAM-to-partner and partner-to-EGFLAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF2 grouped by EGFLAM-low versus EGFLAM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFLAM→partner) and Y-score (partner→EGFLAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EEF2 →	+0.426	+3.169	.009	.009	3	2
URINARY_TRACT	OR10D3 →	+0.107	+4.087	.002	.009	3	1
URINARY_TRACT	H4C7 →	+0.122	+4.087	<.001	.009	3	1
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	1
SOFT_TISSUE	KRTAP17-1 →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	SPANXN4 →	+0.946	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 300 associations by consensus.

EEF2 by EGFLAM expression — LARGE_INTESTINE

Explore this box plot interactively →