Across TCGA pan-cancer cohorts, EGFLAM-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of EGFLAM-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EGFLAM-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EGFLAM-AS1 is over-expressed in tumor.
HNSC, LUAD, and LUSC are the cancer types where EGFLAM-AS1 tumor–normal differential expression is most reproducible.