EGFL8

Across TCGA patient cohorts, EGFL8 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGFL8-associated genes across cancer lineages are CHEK2P5, SLC25A5P9, and MIR4488. Each is linked with EGFL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGFL8-to-partner and partner-to-EGFL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK2P5 grouped by EGFL8-low versus EGFL8-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFL8→partner) and Y-score (partner→EGFL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHEK2P5 →	+0.233	+5.926	<.001	.002	3	2
BRCA	SLC25A5P9 →	+0.068	+5.288	<.001	.006	3	2
LUSC	MIR4488 →	+0.825	+5.093	<.001	.008	3	2
SKCM	H3C15 →	+0.021	+4.508	<.001	.001	3	2
UCEC	RNA5SP422 →	+0.996	+2.448	<.001	.004	3	2
BRCA	RPL12P46 →	+0.273	+6.215	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

CHEK2P5 by EGFL8 expression — BRCA

Explore this box plot interactively →