EGFL8

Across TCGA cell cohorts, EGFL8 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGFL8-associated genes across cancer lineages are ANKRD66, USP17L18, and OR13C9. Each is linked with EGFL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGFL8-to-partner and partner-to-EGFL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD66 grouped by EGFL8-low versus EGFL8-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFL8→partner) and Y-score (partner→EGFL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ANKRD66 →	+0.018	+4.237	<.001	.006	3	1
PANCREAS	USP17L18 →	+0.007	+4.786	<.001	.001	3	1
OVARY	OR13C9 →	+0.041	+4.228	<.001	.006	3	1
SKIN	OR5C1 →	+0.115	+4.977	<.001	.007	3	1
SKIN	TCP10L2 →	+0.149	+5.415	<.001	.004	3	1
LARGE_INTESTINE	SNTG1 →	+0.755	+3.938	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ANKRD66 by EGFL8 expression — PANCREAS

Explore this box plot interactively →