EGF

Across TCGA patient cohorts, EGF protein abundance is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EGF-associated genes across cancer lineages are CRYBB1, PLTP, and POLA1. Each is linked with EGF in more than 1 cancer types. Because this analysis shows association rather than direction, both EGF-to-partner and partner-to-EGF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EGF versus CRYBB1 in GBM, with a Pearson correlation of -0.97.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGF→partner) and Y-score (partner→EGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRYBB1 →	-1.210	-1.217	.005	.003	3	1
GBM	PLTP →	-2.153	-1.606	<.001	.005	3	1
GBM	POLA1 →	+1.153	+1.606	.008	.005	3	1
GBM	ZDHHC15 →	+1.068	+1.208	.003	.004	3	1
GBM	ASAH1 →	-1.299	-1.273	<.001	.009	3	1
GBM	NUDT1 →	+1.273	+1.208	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

EGF vs CRYBB1 — GBM

Explore this scatter interactively →