EGF

Across TCGA pan-cancer cohorts, EGF RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated EGF data layer compared with 11 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher EGF RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EGF expression acts as an unfavorable survival marker, although some lineages such as READ and ACC show a favorable association.

STAD, UVM, and BLCA are the cancer types where EGF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	All	0.604	0.776	<.001	103	view →
UVM	DFS	Tertile	All	0.359	0.733	<.001	94	view →
BLCA	DFS	Quartile	All	0.251	0.502	<.001	70	view →
LIHC	OS	Quartile	All	0.458	0.706	<.001	52	view →
LGG	DFS	Median	All	0.317	0.491	<.001	51	view →
THCA	OS	Tertile	All	0.874	0.986	.008	45	view →
KIRP	OS	Tertile	All	0.585	0.830	<.001	45	view →
UCEC	DFS	Quartile	All	0.768	0.911	<.001	40	view →
THYM	DFS	Quartile	All	0.778	0.972	.001	33	view →
READ	DFS	Median	All	0.854	0.343	<.001	29	view →
ACC	OS	Quartile	II,III,IV	0.846	0.494	.002	26	view →
SKCM	DFS	Quartile	All	0.307	0.181	.003	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

EGF–STAD (OS)

Open the STAD breakdown →