EGF

Across TCGA patient cohorts, EGF mutation is significantly associated with the RNA expression of many other genes, with 6,895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGF-associated genes across cancer lineages are KCTD9, PSMD9, and GTF2H3. Each is linked with EGF in more than 3 cancer types. Because this analysis shows association rather than direction, both EGF-to-partner and partner-to-EGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by EGF-low versus EGF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGF→partner) and Y-score (partner→EGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.701	+1.885	<.001	<.001	3	4
UCEC	PSMD9 →	+0.430	+1.874	<.001	<.001	3	4
SKCM	GTF2H3 →	+0.467	+1.671	.005	.003	3	4
SKCM	BRIX1 →	+0.576	+2.282	<.001	<.001	3	4
SKCM	FARSB →	+0.334	+2.097	.004	.003	3	4
SKCM	ITGB1BP1 →	+0.469	+3.945	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,895 associations by consensus.

KCTD9 by EGF expression — UCEC

Explore this box plot interactively →