EGF

Across TCGA patient cohorts, EGF mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGF-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and eIF4E. Each is linked with EGF in more than 3 cancer types. Because this analysis shows association rather than direction, both EGF-to-partner and partner-to-EGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by EGF-low versus EGF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGF→partner) and Y-score (partner→EGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.546	+1.999	.001	.002	3	4
STAD	Caspase-7-cleavedD198 →	+0.709	+3.169	.034	.018	3	3
UCEC	eIF4E →	+0.164	+1.584	.009	.002	3	3
UCEC	Chk2_pT68 →	-0.143	-1.653	.010	.010	3	3
STAD	ERK2 →	+0.359	+3.459	.009	.005	3	2
STAD	GAPDH →	+0.566	+2.321	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-B1 by EGF expression — UCEC

Explore this box plot interactively →