EGF

Across TCGA cell cohorts, EGF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,255 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible EGF-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Cellular respiration. Each is linked with EGF in more than 12 cancer types. Because this analysis shows association rather than direction, both EGF-to-partner and partner-to-EGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by EGF-low versus EGF-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGF→partner) and Y-score (partner→EGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.128	+1.367	.004	.002	3	13
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.117	+0.895	<.001	.009	3	12
OESOPHAGUS	Cellular respiration →	+0.091	+1.161	<.001	<.001	3	11
OESOPHAGUS	ATP metabolic process →	+0.101	+1.011	<.001	.002	3	11
OESOPHAGUS	Aerobic respiration →	+0.097	+1.162	<.001	<.001	3	11
OESOPHAGUS	Regulation of myoblast fusion →	+0.108	+0.951	<.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,255 associations by consensus.

Negative regulation of myoblast fusion by EGF expression — OESOPHAGUS

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