EGF

Across TCGA cell cohorts, EGF mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGF-associated genes across cancer lineages are H2BC1, C1orf189, and PDCL2. Each is linked with EGF in more than 1 cancer types. Because this analysis shows association rather than direction, both EGF-to-partner and partner-to-EGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by EGF-low versus EGF-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGF→partner) and Y-score (partner→EGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.260	+4.392	<.001	.004	3	1
SOFT_TISSUE	C1orf189 →	+0.223	+3.865	<.001	.006	3	1
SOFT_TISSUE	PDCL2 →	+0.144	+4.295	.002	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.115	+4.392	<.001	.004	3	1
SOFT_TISSUE	CCDC185 →	+0.025	+3.635	.001	.007	3	1
SOFT_TISSUE	OR13D1 →	+0.020	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

H2BC1 by EGF expression — SOFT_TISSUE

Explore this box plot interactively →