EFNB1

Across TCGA patient cohorts, EFNB1 mutation is significantly associated with the RNA expression of many other genes, with 1,367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFNB1-associated genes across cancer lineages are RNU6-1249P, MIR4510, and RNU4-10P. Each is linked with EFNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNB1-to-partner and partner-to-EFNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1249P grouped by EFNB1-low versus EFNB1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNB1→partner) and Y-score (partner→EFNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1249P →	+0.344	+6.571	<.001	.001	3	2
CESC	MIR4510 →	+0.236	+4.757	<.001	.004	3	2
BLCA	RNU4-10P →	+0.315	+7.040	<.001	<.001	3	2
BLCA	RNA5SP30 →	+0.559	+5.251	<.001	.006	3	2
UCEC	SFPQP1 →	+0.041	+1.663	<.001	.005	3	2
UCEC	PSAT1P4 →	+0.104	+1.574	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,367 associations by consensus.

RNU6-1249P by EFNB1 expression — BRCA

Explore this box plot interactively →