EFNA1

Across TCGA patient cohorts, EFNA1 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFNA1-associated genes across cancer lineages are FAM177A1P1, RNU6-380P, and OR5D2P. Each is linked with EFNA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNA1-to-partner and partner-to-EFNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM177A1P1 grouped by EFNA1-low versus EFNA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNA1→partner) and Y-score (partner→EFNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM177A1P1 →	+0.266	+4.326	<.001	<.001	3	2
UCEC	RNU6-380P →	+0.260	+4.885	<.001	.002	3	2
UCEC	OR5D2P →	+0.064	+3.997	.007	.009	3	2
SKCM	OR2P1P →	+0.044	+7.816	<.001	.008	3	1
BRCA	RNU6-58P →	+0.675	+6.112	<.001	.002	3	1
BRCA	RARRES2P5 →	+0.188	+6.711	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

FAM177A1P1 by EFNA1 expression — UCEC

Explore this box plot interactively →