EFL1

Across TCGA pan-cancer cohorts, EFL1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated EFL1 data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher EFL1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated EFL1 expression acts as an unfavorable survival marker.

LUAD, UVM, and READ are the cancer types where EFL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.258	0.670	<.001	36	view →
UVM	OS	Median	II,III,IV	0.218	0.718	.006	24	view →
READ	DFS	Median	III,IV	0.059	0.761	<.001	18	view →
LIHC	DFS	Median	All	0.053	0.556	<.001	9	view →
LUSC	OS	Median	All	0.141	0.830	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	All	0.708	0.872	.016	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

EFL1–LUAD (DFS)

Open the LUAD breakdown →