EFL1

Across TCGA pan-cancer cohorts, EFL1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EFL1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EFL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EFL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where EFL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.907	0.636	.009	18	view →
PDAC	OS	Median	III,IV	0.584	0.303	.008	17	view →
CCRCC	DFS	Median	All	0.987	0.849	.008	12	view →
LSCC	DFS	Quartile	All	0.984	0.868	.019	8	view →
GBM	DFS	Quartile	All	0.445	0.271	.007	6	view →
UCEC	OS	Quartile	All	1.000	0.887	.043	6	view →
LUAD	OS	Quartile	III,IV	1.000	0.391	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EFL1–HNSC (DFS)

Open the HNSC breakdown →