EFL1

Across TCGA cell cohorts, EFL1 mutation is significantly associated with the RNA expression of many other genes, with 361 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFL1-associated genes across cancer lineages are KCNK16, GLT6D1, and FAM24A. Each is linked with EFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFL1-to-partner and partner-to-EFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK16 grouped by EFL1-low versus EFL1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFL1→partner) and Y-score (partner→EFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KCNK16 →	+0.071	+5.000	<.001	.006	3	1
OVARY	GLT6D1 →	+0.409	+5.196	<.001	.005	3	1
BLOOD_Leukemia	FAM24A →	+0.042	+3.969	<.001	.009	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.289	<.001	.009	3	1
BLOOD_Leukemia	PBOV1 →	+0.004	+3.475	<.001	.006	3	1
BLOOD_Lymphoma	OR12D2 →	+0.056	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 361 associations by consensus.

KCNK16 by EFL1 expression — PANCREAS

Explore this box plot interactively →