EFHD1

Across TCGA patient cohorts, EFHD1 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible EFHD1-associated genes across cancer lineages are USP12PY, RNU1-80P, and TRIM53CP. Each is linked with EFHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFHD1-to-partner and partner-to-EFHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP12PY grouped by EFHD1-low versus EFHD1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHD1→partner) and Y-score (partner→EFHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	USP12PY →	+0.049	+5.685	<.001	.003	3	2
UCEC	RNU1-80P →	+0.254	+4.132	<.001	.009	3	2
COAD	TRIM53CP →	+0.043	+6.547	.009	.001	3	2
SKCM	OR8H2 →	+0.137	+4.282	<.001	.009	3	2
LUSC	RN7SKP148 →	+0.219	+5.733	<.001	.001	3	2
LUSC	RPL17P49 →	+0.082	+4.706	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

USP12PY by EFHD1 expression — BLCA

Explore this box plot interactively →