EFEMP1

Across TCGA cell cohorts, EFEMP1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFEMP1-associated genes across cancer lineages are PRLHR, RSPH6A, and ECE2. Each is linked with EFEMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFEMP1-to-partner and partner-to-EFEMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRLHR grouped by EFEMP1-low versus EFEMP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFEMP1→partner) and Y-score (partner→EFEMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRLHR →	+0.023	+5.201	<.001	.006	3	1
LARGE_INTESTINE	RSPH6A →	+0.138	+3.466	<.001	.005	3	1
LARGE_INTESTINE	ECE2 →	+0.242	+3.376	.001	.002	3	1
LARGE_INTESTINE	VAX1 →	+0.744	+3.519	<.001	.007	3	1
LARGE_INTESTINE	NAA11 →	+0.312	+3.706	.007	.002	3	1
LARGE_INTESTINE	SSMEM1 →	+0.028	+3.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PRLHR by EFEMP1 expression — BLOOD_Leukemia

Explore this box plot interactively →