Across TCGA patient cohorts, EFCAB7 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFCAB7-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Bax, and 4E-BP1_pT37_T46. Each is linked with EFCAB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFCAB7-to-partner and partner-to-EFCAB7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB7→partner) and Y-score (partner→EFCAB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.628	-3.000	<.001	<.001	3	2
UCEC	Bax →	+0.227	+2.222	.010	.009	3	2
UCEC	4E-BP1_pT37_T46 →	-0.381	-1.502	.005	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.561	+2.242	.010	.005	3	2
UCEC	eEF2 →	+0.385	+1.502	.003	.030	3	1
UCEC	EGFR →	-0.171	-2.433	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

EFCAB7 survival (RNA) · tumor vs normal (RNA) · all EFCAB7 data types