EFCAB5

Across TCGA cell cohorts, EFCAB5 mutation is significantly associated with the RNA expression of many other genes, with 179 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFCAB5-associated genes across cancer lineages are CLGN, ALKBH2, and CELA2B. Each is linked with EFCAB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFCAB5-to-partner and partner-to-EFCAB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLGN grouped by EFCAB5-low versus EFCAB5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB5→partner) and Y-score (partner→EFCAB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLGN →	+1.049	+2.800	.001	.001	3	2
LARGE_INTESTINE	ALKBH2 →	+0.858	+3.743	<.001	<.001	3	2
SKIN	CELA2B →	+0.043	+3.619	<.001	<.001	3	2
STOMACH	KHDC3L →	+0.016	+3.662	<.001	.001	3	2
BLOOD_Leukemia	TMEM178B →	+0.404	+2.632	<.001	.009	3	2
URINARY_TRACT	CCDC196 →	+0.014	+4.044	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 179 associations by consensus.

CLGN by EFCAB5 expression — LARGE_INTESTINE

Explore this box plot interactively →